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  • Journal article
    DALLMAN MJ, CLARK GJ, 1991,

    CYTOKINES AND THEIR RECEPTORS IN TRANSPLANTATION

    , CURRENT OPINION IN IMMUNOLOGY, Vol: 3, Pages: 729-734, ISSN: 0952-7915
  • Journal article
    PAGE TH, DALLMAN MJ, 1991,

    MOLECULAR-CLONING OF CDNAS FOR THE RAT INTERLEUKIN-2 RECEPTOR ALPHA-CHAIN AND BETA-CHAIN GENES - DIFFERENTIALLY REGULATED GENE ACTIVITY IN RESPONSE TO MITOGENIC STIMULATION

    , EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 21, Pages: 2133-2138, ISSN: 0014-2980
  • Journal article
    DALLMAN MJ, LARSEN CP, MORRIS PJ, 1991,

    CYTOKINE GENE-TRANSCRIPTION IN VASCULARIZED ORGAN GRAFTS - ANALYSIS USING SEMIQUANTITATIVE POLYMERASE CHAIN-REACTION

    , JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 174, Pages: 493-496, ISSN: 0022-1007
  • Journal article
    MONTGOMERY RA, DALLMAN MJ, 1991,

    ANALYSIS OF CYTOKINE GENE-EXPRESSION DURING FETAL THYMIC ONTOGENY USING THE POLYMERASE CHAIN-REACTION

    , JOURNAL OF IMMUNOLOGY, Vol: 147, Pages: 554-560, ISSN: 0022-1767
  • Journal article
    DALLMAN MJ, MONTGOMERY RA, LARSEN CP, WANDERS A, WELLS AFet al., 1991,

    CYTOKINE GENE-EXPRESSION - ANALYSIS USING NORTHERN BLOTTING, POLYMERASE CHAIN-REACTION AND INSITU HYBRIDIZATION

    , IMMUNOLOGICAL REVIEWS, Vol: 119, Pages: 163-179, ISSN: 0105-2896
  • Journal article
    DALLMAN MJ, SHIHO O, PAGE TH, WOOD KJ, MORRIS PJet al., 1991,

    Peripheral tolerance to alloantigen results from altered regulation of the interleukin-2 pathway

    , Journal of Experimental Medicine, Vol: 173, Pages: 79-87, ISSN: 0022-1007

    Tolerance to alloantigen may be induced in rats by administration of blood followed by transplantation of a renal allograft. The mechanism of this tolerance was investigated by directly analyzing the functional activity of graft-infiltrating cells. We have previously shown cytotoxic T lymphocyte infiltration of, and major histocompatibility complex induction on, grafts of tolerant animals. We now report that cells isolated from the grafts of tolerant rats show a reduced expression of the p55 interleukin 2 receptor (IL-2R) chain on the cell surface compared with that seen on the cells of untreated animals. Scatchard analysis further reveals low expression of high affinity IL-2R. This is due to reduced transcription of both IL-2R alpha and beta chain mRNAs and results in a reduced ability of cells to proliferate in response to IL-2. Cells isolated from tolerant animals are unable to make biologically active IL-2 in culture, whereas cells from untreated animals make high levels. This is not reflected at the mRNA level as the IL-2 gene is induced in both tolerant and untreated animals to similar levels. The induction of tolerance is abrogated by administration of recombinant IL-2 to animals at the time of transplantation. Thus, we conclude that an altered regulation of the IL-2 pathway results in tolerance in these alloantigen-treated and transplanted animals.
  • Conference paper
    MORRIS PJ, WOOD KJ, DALLMAN MJ, 1991,

    ANTIGEN-INDUCED TOLERANCE TO ORGAN ALLOGRAFTS

    , CONF ON ANTIGEN AND CLONE-SPECIFIC IMMUNOREGULATION, Publisher: NEW YORK ACAD SCIENCES, Pages: 295-305, ISSN: 0077-8923
  • Conference paper
    JAISSER F, BUGEON L, PRADELLES P, BONVALET JP, FARMAN Net al., 1991,

    KINETICS OF AVP-INDUCED PGE2 SYNTHESIS IN THE RABBIT CORTICAL COLLECTING TUBULE

    , 3RD INTERNATIONAL VASOPRESSIN CONF, Publisher: INST NATL SANTE RECHERCHE MEDICALE, Pages: 503-510
  • Conference paper
    CLARKE DJ, HONEY CR, DALLMAN MJ, CHARLTON HMet al., 1991,

    SURVIVAL OF HUMAN FETAL GRAFTS IN A RAT MODEL OF PARKINSONS-DISEASE - ALTERNATIVE METHODS OF IMMUNOSUPPRESSION

    , 20TH FERNSTROM SYMP ON INTRACEREBRAL TRANSPLANTATION IN MOVEMENT DISORDERS : EXPERIMENTAL BASIS AND CLINICAL EXPERIENCES, Publisher: ELSEVIER SCIENCE PUBL B V, Pages: 193-197
  • Conference paper
    FARGES O, DALLMAN MJ, MORRIS PJ, 1991,

    PHENOTYPIC AND FUNCTIONAL-STUDY OF GRAFT INFILTRATING CELLS IN RAT-LIVER TRANSPLANTATION

    , INTERNATIONAL WORKSHOP ON EXPERIMENTAL AND CLINICAL LIVER TRANSPLANTATION, Publisher: ELSEVIER SCIENCE PUBL B V, Pages: 37-38
  • Journal article
    Honey CR, Clarke DJ, Dallman MJ, Charlton HMet al., 1990,

    Human neural graft function in rats treated with anti-interleukin II receptor antibody.

    , Neuroreport, Vol: 1, Pages: 247-249, ISSN: 0959-4965

    Prolonged immunosuppression with cyclosporin A allows survival of human xenografts in the rat Parkinsonian model but the drug has side effects. Ideally immunosuppression should be of short duration, to minimize the chance of infection, yet be capable of supporting long term survival of the transplanted tissue. We report that short term treatment with an anti-rat interleukin II receptor (IL2R) monoclonal antibody (MAb) resulted in apparently permanent survival of human fetal dopaminergic grafts in "Parkinsonian" rats. The recipients remained healthy and the excellent survival of the transplants suggests that the antibody injection strategy would almost certainly abrogate allograft rejection and raises the possibility that xenogenic dopaminergic neurones could be used as donor tissue in humans.
  • Journal article
    SUTTON R, GRAY DWR, MCSHANE P, DALLMAN MJ, MORRIS PJet al., 1989,

    THE SPECIFICITY OF REJECTION AND THE ABSENCE OF SUSCEPTIBILITY OF PANCREATIC-ISLET BETA-CELLS TO NONSPECIFIC IMMUNE DESTRUCTION IN MIXED STRAIN ISLETS GRAFTED BENEATH THE RENAL CAPSULE IN THE RAT

    , JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 170, Pages: 751-762, ISSN: 0022-1007
  • Journal article
    HUGHES DA, BITTAR CM, GLOVER LG, DALLMAN MJ, RICHARDSON AJ, MORRIS PJet al., 1989,

    ANALYSIS OF CELL-POPULATIONS IN FINE NEEDLE ASPIRATION BIOPSIES FROM HUMAN RENAL-ALLOGRAFTS BY SEPARATION ON A PREFORMED CONTINUOUS PERCOLL DENSITY GRADIENT

    , TRANSPLANTATION PROCEEDINGS, Vol: 21, Pages: 3591-3592, ISSN: 0041-1345
  • Journal article
    JAISSER F, BUGEON L, BLOTCHABAUD M, BONVALET JP, FARMAN Net al., 1989,

    EFFECTS OF AVP AND DDAVP ON PGE2 SYNTHESIS IN SUPERFUSED CORTICAL COLLECTING TUBULES

    , AMERICAN JOURNAL OF PHYSIOLOGY, Vol: 256, Pages: F1044-F1050, ISSN: 0002-9513
  • Journal article
    WOOD KJ, DALLMAN MJ, MORRIS PJ, 1989,

    CYTO-TOXIC CELLS ALONE ARE NOT SUFFICIENT TO MEDIATE RENAL GRAFT-REJECTION

    , TRANSPLANTATION PROCEEDINGS, Vol: 21, Pages: 338-339, ISSN: 0041-1345
  • Journal article
    DALLMAN MJ, WOOD KJ, MORRIS PJ, 1989,

    RECOMBINANT INTERLEUKIN-2 (IL-2) CAN REVERSE THE BLOOD-TRANSFUSION EFFECT

    , TRANSPLANTATION PROCEEDINGS, Vol: 21, Pages: 1165-1167, ISSN: 0041-1345
  • Journal article
    TELLIDES G, DALLMAN MJ, MORRIS PJ, 1989,

    MECHANISM OF ACTION OF INTERLEUKIN-2 RECEPTOR (IL-2R) MONOCLONAL-ANTIBODY (MAB) THERAPY - TARGET-CELL DEPLETION OR INHIBITION OF FUNCTION

    , TRANSPLANTATION PROCEEDINGS, Vol: 21, Pages: 997-998, ISSN: 0041-1345
  • Journal article
    SUTTON R, GRAY DWR, PETERS M, MCSHANE P, DALLMAN M, MORRIS RJet al., 1989,

    SPECIFICITY OF PANCREATIC-ISLET ALLOGRAFT-REJECTION IN MIXED STRAIN RAT ISLET TRANSPLANTS

    , TRANSPLANTATION PROCEEDINGS, Vol: 21, Pages: 2680-2681, ISSN: 0041-1345
  • Journal article
    DALLMAN MJ, PORTER ACG, LARSEN CP, MORRIS PJet al., 1989,

    LYMPHOKINE PRODUCTION IN ALLOGRAFTS - ANALYSIS OF RNA BY NORTHERN BLOTTING

    , TRANSPLANTATION PROCEEDINGS, Vol: 21, Pages: 296-298, ISSN: 0041-1345
  • Journal article
    DALLMAN MJ, WOOD KJ, MORRIS PJ, 1988,

    CYTO-TOXICITY AND IL-2-REACTIVITY OF CELLS FROM REJECTED OR NONREJECTED ALLOGRAFTS

    , TRANSPLANTATION PROCEEDINGS, Vol: 20, Pages: 226-228, ISSN: 0041-1345
  • Journal article
    WOOD KJ, HOPLEY A, DALLMAN MJ, MORRIS PJet al., 1988,

    LACK OF CORRELATION BETWEEN THE INDUCTION OF DONOR CLASS-I AND CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS AND GRAFT-REJECTION

    , TRANSPLANTATION, Vol: 45, Pages: 759-767, ISSN: 0041-1337
  • Journal article
    TELLIDES G, DALLMAN MJ, MORRIS PJ, 1988,

    SYNERGISTIC INTERACTION OF CYCLOSPORINE-A WITH INTERLEUKIN-2 RECEPTOR MONOCLONAL-ANTIBODY THERAPY

    , TRANSPLANTATION PROCEEDINGS, Vol: 20, Pages: 202-206, ISSN: 0041-1345
  • Journal article
    WOOD KJ, DALLMAN MJ, MORRIS PJ, 1988,

    INDUCTION OF DONOR MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS MAY NOT ALWAYS CORRELATE WITH GRAFT-REJECTION

    , TRANSPLANTATION PROCEEDINGS, Vol: 20, Pages: 264-266, ISSN: 0041-1345
  • Journal article
    TELLIDES G, DALLMAN MJ, MORRIS PJ, 1987,

    NDS-61, A NEW MONOCLONAL-ANTIBODY TO THE RAT INTERLEUKIN-2 RECEPTOR (IL-2 R) INDUCES LONG-TERM ALLOGRAFT SURVIVAL

    , BRITISH JOURNAL OF SURGERY, Vol: 74, Pages: 1145-1146, ISSN: 0007-1323
  • Journal article
    TELLIDES G, DALLMAN MJ, KUPIECWEGLINSKI JW, DIAMANTSTEIN T, MORRIS PJet al., 1987,

    FUNCTIONAL BLOCKING OF THE INTERLEUKIN-2 RECEPTOR (IL-2R) MAY BE IMPORTANT IN THE EFFICACY OF IL-2R ANTIBODY THERAPY

    , TRANSPLANTATION PROCEEDINGS, Vol: 19, Pages: 4231-4233, ISSN: 0041-1345
  • Journal article
    DALLMAN MJ, WOOD KJ, MORRIS PJ, 1987,

    CYTOTOXIC ACTIVITY IN TRANSFUSED AND UNTREATED RATS FOLLOWING RENAL-TRANSPLANTATION

    , TRANSPLANTATION PROCEEDINGS, Vol: 19, Pages: 3119-3122, ISSN: 0041-1345
  • Journal article
    DALLMAN MJ, WOOD KJ, MORRIS PJ, 1987,

    SPECIFIC CYTOTOXIC T-CELLS ARE FOUND IN THE NONREJECTED KIDNEYS OF BLOOD-TRANSFUSED RATS

    , JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 165, Pages: 566-571, ISSN: 0022-1007
  • Journal article
    MCWHINNIE DL, DALLMAN MJ, MORRIS PJ, 1987,

    THE INFLUENCE OF CYCLOSPORINE ON CELLULAR INFILTRATION IN RAT RENAL-ALLOGRAFTS

    , TRANSPLANTATION PROCEEDINGS, Vol: 19, Pages: 345-347, ISSN: 0041-1345
  • Journal article
    WOOD KJ, DALLMAN MJ, MORRIS PJ, 1987,

    BLOOD-TRANSFUSION INDUCES SPECIFIC CYTOTOXIC-CELLS

    , TRANSPLANTATION PROCEEDINGS, Vol: 19, Pages: 1458-1460, ISSN: 0041-1345
  • Journal article
    WEYAND CM, GORONZY J, DALLMAN MJ, FATHMAN CGet al., 1986,

    ADMINISTRATION OF RECOMBINANT INTERLEUKIN-2 INVIVO INDUCES A POLYCLONAL IGM RESPONSE

    , JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 163, Pages: 1607-1612, ISSN: 0022-1007

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